A very good article on The Statistical Analysis of fMRI Data Martin A. Lindquist avaiable for download.
Abstract. In recent years there has been explosive growth in the number
of neuroimaging studies performed using functional Magnetic Resonance
Imaging (fMRI). The field that has grown around the acquisition and analysis
of fMRI data is intrinsically interdisciplinary in nature and involves contributions
from researchers in neuroscience, psychology, physics and statistics,
among others. A standard fMRI study gives rise to massive amounts of noisy
data with a complicated spatio-temporal correlation structure. Statistics plays
a crucial role in understanding the nature of the data and obtaining relevant
results that can be used and interpreted by neuroscientists. In this paper we
discuss the analysis of fMRI data, from the initial acquisition of the raw data
to its use in locating brain activity, making inference about brain connectivity
and predictions about psychological or disease states. Along the way,
we illustrate interesting and important issues where statistics already plays a
crucial role.We also seek to illustrate areas where statistics has perhaps been
underutilized and will have an increased role in the future.
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